• 27.29 28.65 • • 0.808 0.360 • • 0.10 0.05 Multimer • 46.23 • 2.575 • 0.29 Insulin Human USP Standard Identity Retention Time Peak Area Relative Area % Insulin • 21.06 • 1275.883 • 98.35 A5/B4 Desamido • 23.29 • 3.084 • 0.23 • 25.36 • 0.330 • 0.05 A21 Desamido •

has the same peaks as USP Insulin, however, it has fewer contaminants Related Substances R & D Insulin Drug Substances Identity Retention Time Peak Area Relative Area Insulin • 21.19 • 884.701 • 99.11 A5/B4 Desamido • 22.96 • 0.842 • 0.11 • 26.3 • 0.508 • 0.07 A21 Desamido • 27.