for USP Grade Insulin-Humulin Physiochemical Composition Physiochemical Property Value Amino acid sequence Amino acid composition Peptide map Disulfide bridges Molecular weight Isoform pattern Electrophoretic patterns Liquid chromatographic patterns Potency ♦ Equivalent to insulin hormone, USP

the Doctrine of Equivalence for USP Grade Insulin-Humulin Physiochemical Property Value Amino acid sequence Amino acid composition Peptide map Disulfide bridges Molecular weight Isoform pattern Electrophoretic patterns Liquid chromatographic patterns Potency • Equivalent to insulin hormone, USP

des Group - Publications Page 20 of 31 1993, 115, 10714-10721. 364. "Interpretation of the Reduction Potential of 6,6'-Dideoxy-6,6'-Dithiosucrose Disulfide by Comparison of the Conformations of 6,6'-Dideoxy-6,6'-Dithiosucrose Disulfide, 6,6'- Dideoxysucrose-6,6'-Dithiol, and Sucrose in Aqueous Solu