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0 1.1400 O U. 4600 Meth Af6, 3 = -83.6(MAC) -' 6'-22.4 R2 = 0.999 p = le -3 0.10 1.00 10.00 100.00 Minimum Alwoolar Concentrallon, MAC (% alan) 1,000.00 Figure 4. Change in tubulin collective dipole modes due to the addition of anesthetic/non-anesthetic molecules for different binding sit

anesthetic agents by van der Waals-type London dispersion forces. To determine if there is a preferred binding site on tubulin for all anesthetics, ANOVA analysis was run to compare anesthetic binding at each site. Figure S1 provides a graphical illustration of the distribution of binding SCIENTIFIC

ber 2011 Accepted 28 October 2011 Action editor Alan Beaton Published online 19 November 2011 Keywor

ively, while Pig. 2B and C shows post-Bonferroni significant asymmetries for each sex. Although Pigs. 1 and 2 appear to suggest sex differences, an ANOVA failed to reveal significant interactions between sex and laterality in any ROI. 4. Discussion In this study we intentionally adopted a conservat

ber 2011 Accepted 28 October 2011 Action editor Alan Beaton Published online 19 November 2011 Keywor

ively, while Fig. 28 and C shows post-Bonferroni significant asymmetries for each sex. Although Figs. 1 and 2 appear to suggest sex differences, an ANOVA failed to reveal significant interactions between sex and laterality in any ROI. 4. Discussion In this study we intentionally adopted a conservat