Cash, Stock Option Requirements 2014-2015 Confidential SCHRoDINGER. EFTA00293496

Recent changes to projections • 01 sales were $12.1M (2013: $9.4M). • Q2 sales projected to be $8.2M (2013: $5.3M) • Headcount was expected to grow by 20 in 01; instead grew by 2 • Therefore... 2014 revenue higher, expenses lower, vs. prior projection SCHRoDINGER. EFTA00293497

Income Statement & Cash 2012 2013 2014 2015 Revenue 32,657 33,912 37,456 48,223 Cost of Goods Sold 4,007 4,612 4,917 6,562 Gross Profit 28,650 29,300 32,539 41,661 Research & Development 15,611 20,230 23,455 24,306 Sales & Marketing 9,068 11,688 12,352 14,735 General & Administrative 7,271 9,196 9,575 10,597 Operating Expense 31,949 41,114 45,382 49,637 Other Income/Expense (466) (65) (200) (200) Net Income (3,765) (11,879) (13,043) (8,176) Cash at end of year 31,975 19,836 10,630 8,571 SCHRODINGER. EFTA00293498

Expected Cash Available Cash (in millions) 40 35 30 25 20 15 10 0 —Current Best Unbiased Estimate — Zero Sales Growth Scenario • 4) 4.) or°` e e to' • el, 1, n, es ,0„; cy„ s,„)y SCHRODINGER. EFTA00293499

Option Pool 2010 Stock Option Plan 25 Options (in millions) 20 - 15 10 5 —Authorized —Outstanding o N• N• 0, ON' 0› t0, " ON' ON' ON' O 1, 'V '1, `1, 1, fl, ,r191 se se se ,k, se & P-9 & P.9;1/ & P9 & PC/ 7.9 million shares in pool remain after today SCHRoDINGER. EFTA00293500