6/2012 Jazayeri-Dezfuly et al. (75) Inventors: Shugnang Zhang, Lexington, MA (US); FOREIGN PATENT DOCUMENTS Alexander Rich, Cambridge, MA (US); Karol na Corin. Irvine, CA (US); Lotto EP 1270724 A2 • 2/2003 Cl2N 15/12 T.1Cgler. Linkoping (SE) WO WO 2007/089899 • 2/2007 C07K 14/705 WO 2008/114