ROTEINS AND METHODS FOR THE PREPARATION AND USE THEREOF 2011/0028700 Al 212011 Heal 2011/0046351 Al 2/2011 Weir et al. 201110112037 Al 5/2011 Warne et al. 2012/0165507 Al 6/2012 Jazayeri-Dezfuly et al. (75) Inventors: Shugnang Zhang, Lexington, MA (US); FOREIGN PATENT DOCUMENTS Alexander Rich, Camb