n=61) @ CBD (n=61) @ Placebo (n=59) Bi Placebo (n=59) 50 50 45 p~0.0123 45 < = 40 p=0.0234 = = 35 3 3 3S 30 go oO i = 5. aS x s g 2 3 B ob = = 10 5 ° Treatment Period Maintenance Period Treatment Period Maintenance Period (Primary) Source: GW Pharma, AES 2016 The most common adverse events were reported to be somnolence (36% in patients on Epidiolex vs. 10% in place