• EPB-510 has sub-pM in vitro HCV repl icon activity • Rang of actmtrmry similar to other UPIs enduring GS.7977 • Series Is equipotent against GT la & lb • Unique resistance pattern compared to G5-7977 & INX-08189 • 5282T muldon associated with resistance to T-C-rnethylated compounds (2*CrneCI