n clinical exome and genome sequencing Robert C. Green, MD, MPhlu, Jonathan S. Berg, MD, PhD3, Wayne W. Grody, MD, PhD", Sarah S. Kalia, ScM, CGC', Bruce R. Korf, MD, PhD7, Christa L. Martin, PhD, FACMG8, Amy L. McGuire, JD, PhD°, Robert L. Nussbaum, MD10, Julianne M. O'Daniel, MS, CGC3, Kelly E. Ormond, MS,