The final ver- sion of this article and its recommendations do not necessarily reflect the views of these individuals. DISCLOSURE L.G.B., J.S.B., W.W.G., C.L.M., A.M., R.L.N., K.E.O., and H.L.R. have grants related to genome sequencing. L.G.B. and H.L.R. ACMG POLICY STATEMENT receive in-kind resear