JAMA 2014; 311:363.77. 4. Avom J. Approval of a tuberculosis drug based on a paradoxical surrogate measure. JAMA 2013:309:1349-50. 5. Dhruva SS. Bero LA. Redberg RF. Strength of study evidence examined by the FDA in premarket approval of cardiovascular devic- es. JAMA 2009;302:2679-1M DOI: 10.1056/