approximately one year later. 3 IFage EFTA R1_02139718 EFTA02714284 BREMNER CAPITAL MANAGEMENT Tekmira Pharmaceuticals March 2014 • TKM — ALDH2 is a unique application of RNAi and is designed to knockdown the Aldehyde dehydrogenase 2 (ALDH2) enzyme to induce long term sensitivity to ethanol.