.20 $16.37 $4.40 MktCap ($bn) Share Price(S) $564.4 $728.3 $222.5 $505.07 $32.20 $16.37 $4.40 Alnylam Pharma MIN US Opko Health OPK US Isis Pharma ISIS US Avg RNAI (late stage) $63.97 $9.08 $42.90 $4,088.8 $3,652.0 $4,873.8 54,204.87 $63.97 $9.08 $42.90 Avg Total $2,355 6 'Page E