quirements for effective malaria control with 230 homing endonuclease genes. Proc. NatL Acad. Sci. U. S. A. 108, E874-80 (2011). 231 21. Khanna, K. K. & Jackson, S. P. DNA double-strand breaks: signaling, repair and the 232 cancer connection. Nat. Genet. 27, 247-254 (2001). 233 22. Vilenchik, M. M. & Knu