, B. a. Confinement of gene drive systems to local populations: A 215 comparative analysis. J. Theor. Biol. 294,153-171 (2012). 216 13. Sinkins, S. P. & Gould, F. Gene drive systems for insect disease vectors. Nat. Rev. Genet 217 7, 427-435 (2006). 218 14. Charlesworth, B. & Langley, C. H. The populati