rison of nonhomologous 237 end joining and homologous recombination in human cells. DNA Repair (Amst). 7, 1765- 238 71 (2008). 239 24. DiCarlo, J. E. et at Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas 240 systems. Nucleic Acids Res. 41, 4336-43 (2013). 241 25. Griffiths A. J. F