e population genetics of using homing 228 endonuclease genes in vector and pest management. Genetics 179, 2013-2026 (2008). 229 20. Deredec, A., Godfray, H. C. J. & Burt, A. Requirements for effective malaria control with 230 homing endonuclease genes. Proc. NatL Acad. Sci. U. S. A. 108, E874-80 (20