ystem in the 205 human malaria mosquito. Nature 473,212-215 (2011). 206 7. Windbichler, N. et at. Homing endonuclease mediated gene targeting in Anopheles 207 gambiae cells and embryos. Nucleic Acids Res. 35,5922-33 (2007). 208 8. Gurwitz, D. Gene drives raise dual-use concerns. Science (80-. ). 34