enter for =iotechnology Information, U.S. National Library of =edicine8600 Rockville Pike, Bethesda 20894 USA In partnership =ith: AHRQ: Agency for Healthcare Research and Quality <http://www.ahrq.govi> The Cochrane Collaboration chttp://www.cochrane.org/> IQWIG: German Institute for Quality and Efficiency in =ealth Care <htt