(mean, 10,848 ± 523 SD) were also of a functional class that could potentially be disease causative (Fable 1) (25-27). Of these, —14% (mean, 1530 ± 518 SD) had an allele fiequen- cy that was sufficiently low to be a candidate for being causative in an uncommon disease (<1% allele frequency in 836 indiv