, of which a mean of 1.87 ± 0M9 million (SD) were se-striated with protein-encoding genes (Table 1). Less than I% of these variants (mean, 10,848 ± 523 SD) were also of a functional class that could potentially be disease causative (Fable 1) (25-27). Of these, —14% (mean, 1530 ± 518 SD) had an allele