and intronic targets, totaling 2.1 million nucleotides (table SI) (2, 33). The exome and CMH-Dx1 methods, which used Illumina TruSeq enrichment and HiSeq 2000 sequencing, took —19 days. In contrast, rapid WGS did not use target enrichment, was performed with the HiSeq 2500 instrument, and took —50 hours.