ecluded, by the use of an RNA-guided gene 123 drive system employing multiple guide RNAs which all target a particular locus, as suggested by 124 Esvelt et a12. If cutting were induced by two or more guides simultaneously, then repair by NHEJ 125 would result in a loss of the intervening sequence an

rency Initiative - Rob Ali, Madars Virz= and Neha Narula 2:30-3:00 - Just Joi 3:00-4:00 - Meeting about One Science - Professors - Hugh Herr, Kevin=Esvelt, Ed Boyden - Joi please note The info=mation contained in this communication is confidential, may be attorney=client privileged, may constitute i