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25,511-557 (1991). EFTA00591455 223 17. Mali, P. et aL RNA-guided human genome engineering via Cas9. Science 339, 823-6 224 (2013). 225 18. Simoni, A. et aL Development of synthetic selfish elements based on modular nucleases in 226 Drosophila melanogaster. Nucleic Acids Res. 42, 7461-72 (2014