okers) K Controls (Nonsmokers) ■ Ever-Users (Smokers) ■ Controls (Smokers) 250 200 — 150 — 100 — 50 — 0 15-24 25-34 35-44 45- Age Layde PM, Beral V. Lancet 1981;1:541-546. Oral contraceptives may compound the effects of well-known risk factors, such as hypertension, diabetes, hyperlipidemias, ag