category 1 to 4 variants are a subset of gene- (5 associated variants. L'" ets n 2 or High- ACMG ACMG ACMG Candidate Run Sampletime nor Mitochondria )genome Nuclear Sequence quality genome Gene- categories categories categories 1 to 4 1 to 3 Candidate gene Candidate c ° (hours) varian

ed, there is no cell toxicity after delivery under appropriate conditions, and delivery efficiency is over 80% depending on different cell types. Mitochondria delivered by the PMD system will move to the original mitochondrial location in the cells and will not be catalyzed in lysosomes; thus, the thera