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selection and the concept of a protein space. Nature 115: 563-564. 20. Fontana W, Schuster P (1987) A computer model of evolutionary optimiration. Binphys Chem 26: 123-147. 21. Fontana W. &hinter P (1998) I:ontinnity in evolution: On the nature cal' transition. Science 280: 1451-1455. 22. Eigen M. Mccaskill
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