WTeases122::pcas.5— vi. WT •sis2::pcas7— Fig. 3. CRISPR spacer engineering, cos gene inactivation, and corresponding phage sensi- tivity. I, mutant WTItts' s 2; II, mutan WT,pess• sis2ACRISPR1 in which CRISPR1 was deleted; Ill, mutant WToesan '::pR in which CRISPR1 was displaced and replaced with a uni