es in Prokaryotes Rodolphe Barrangou,' Christophe Fremaux,2 Hake Deveau,3 Melissa Richards,' Patrick Boyava1,2 Sylvain Moineau,3 Dennis A. Romero,' Philippe Horvath's' Clustered regularly interspaced short palindromic repeats (CRISPR) are a distinctive feature of the genomes of most Bacteria and Archaea and are t