r alpha-beta tubulin stability, and may be a mechanism by which volatile anesthet- ics disrupt microtubule structureS0. Quantum Chemical Estimate of Polarizability and MAC. We calculated the mean polarizability and polarizability tensors for all It agents listed in Fig. 1 using a density functional theory appr

e regions are composed largely of highly polarizable, it-resonance clouds of aromatic amino acids such as tryptophan, tyrosine, and phe- nylalanine. Polarizability, which refers to the degree to which a molecule can be instantaneously polarized by nearby charge distributions, correlates strongly with anesthetic