ow that fructose increased jejunal NaCI and water absorption which was significantly decreased in mice whose apical chloride/base exchanger Slc26a6 (PAT1, CFEX) was EFTA00666020 knocked out. Increased dietary fructose intake enhanced expression of this transporter as well as the fructose- absorbing

ted the expression of NHE3, PAT1 and GlutS in the intestine and resulted in hypertension in wild-type mice, a response that was almost abolished in PAT1 null mice and abrogated in GlutS null mice. This article will discuss the interaction of GlutS with salt-absorbing transporters and review the role