% improvement compared to placebo • Placebo effect from literature is 22%' • Secondary endpoints- bone turnover markers a veru Lopinzi el o12009. Annals of Oncology p1 .8 ICOLI0.I093/annenc/mcfn644 :Table 21 0 mg Primary endpoint Primary endpoint 4 weeks 12 weeks 7 EFTA00810558 Zuclomiphene: greater th