y Epstein <[email protected]> To: "Kaptchuk, Ted Jack" Subject: Re: Date: Wed, 24 Nov 2010 09:55:59 +0000 Ted „ as you may know, I funded the Placebo work, with AnnHarrington probably fifteen years ago. I was one of the originals on the MBB commitee, being best friends with Henry Rososvskly. then

f Medicine Harvard Medical School Boston, MA 02215 hone: On Nov 24, 2010, at 4:55 AM, Jeffrey Epstein wrote: Ted „ as you may know, I funded the Placebo work, with AnnHarrington probably fifteen years ago. I was one of the originals on the MBB commitee, being best friends with Henry Rososvskly. then

f Medicine Harvard Medical School Boston MA 02215 phone: On Nov 24, 2010, at 4:55 AM, Jeffrey Epstein wrote: Ted „ as you may know, I funded the Placebo work, with AnnHarrington probably fifteen years ago. I was one of the originals on the MBB commitee, being best friends with Henry Rososvskly. then

f Medicine Harvard Medical School Boston, MA 02215 hone: On Nov 24, 2010, at 4:55 AM, Jeffrey Epstein wrote: Ted „ as you may know, I funded the Placebo work, with AnnHarrington probably fifteen years ago. I was one of the originals on the MBB commitee, being best friends with Henry Rososvskly. then

n by Baseline Score 80 70 • 1 60 • (7) 50 • • 40 S 30 • `6 20 • • 10 • 0i 0 I 1 2 3 4 Baseline score Figure 3. Effect of VIAGRA and Placebo on Maintenance of Erection by Baseline Score. O0 M1 M2 O3 M4 O5 O0 • 1 E2 O3 E4 M5 The frequency of patients reporting improvement of e

nter Boston, MA 02215 Phone: Email: Web: On Nov 24, 2010, at 4:55 AM, Jeffrey Epstein wrote: EFTA00687388 Ted „ as you may know, I funded the Placebo work, with AnnHarrington probably fifteen years ago. I was one of the originals on the MBB commitee, being best friends with Henry Rososvskly. then

To: Kaptchuk, Ted Jack From: Jeffrey Epstein Sent Wed 11/24/2010 9:55:59 AM Subject: Re: Ted „ as you may know, I funded the Placebo work, with AnnHarrington probably fifteen years ago. I was one of the originals on the MBB commitee, being best friends with Henry Rososyskly. then

enter Boston. MA 02215 rq EFTA_R1_00026487 EFTA01738715 On Nov 24, 2010, at 4:55 AM, Jeffrey Epstein wrote: Ted „ as you may know, I funded the Placebo work, with AnnHarrington probably fifteen years ago. I was one of the originals on the MBB commitee, being best fiends with Henry Rososyskly. then

sis, a statistical technique for extracting information from studies that are not statistically significant by them- selves. Their article, "Is the Placebo Pow- erless? An Analysis of Clinical Trials Comparing Placebo with No Treat - ment," published in The New England Journal ofMeditine, was a long-o

essor of Medicine Harvard Medical School Boston, MA 02215 On Nov 24, 2010, at 4:55 AM, Jeffrey Epstein wrote: Ted „ as you may know, I funded the Placebo work, with AnnHarrington probably fifteen years ago. I was one of the originals on the MBB commitee, being best friends with Henry Rososyskly. then

pidiolex 20mg/kg (n=50) Epidiolex 20 mg/kg (n=50) ie Part A Complete Dose Selection Screening Randomization Open Label Extension Randomized 1:1 — Placebo (n=50) t Primary Endpoint: % change from baseline in monthly drop seizure frequency during the 14 week treatment period compared with the 4 week bas