, Neurocrine Biosciences Inc, NPS Pharmaceuticals, Ophthotech Corp. Pharmacyclics Inc.. Portola Pharmaceuticals Inc. Regeneron Pharmaceuticals Inc., Relypsa. Inc.. Synageva Biopharma Corp, Theravance Inc, Ultragenyx Pharmaceutical Inc, Versartis. Inc., Vertex Pharmaceuticals, XenoPort Inc. Within the la

mber of successful start-up companies. These have included Pearl Therapeutics (NLV-I, exited in sale to Astra Zeneca, 2.5x multiple plus milestones), Relypsa (NLV-I,_ private initially, now public on NASDAQ: RLYP), Convergence/Calchan Pharmaceuticals (NLV-IL, one start up that subsequently split to become