On Mon, Jun 22, 2015 at 1:41 AM, Peter Attia MIIIMI IIMINIMm wrote: Here is manifesto. Substrate for long discussion. I even open with a quote from PT. I wrote this last summer, so it's a bit dated relative to my recent thinking. Re: sleep, most evidence says 7.5 to 8.5 hours, even as adults. From: jeffrey E. [mailto:[email protected] <mailto:[email protected]> ] Sent: Sunday, June 21, 2015 10:24 PM To: Peter Attia Subject: Re: JASON no you did not. Im not sure how to titrate what to tweak. . if a baby sleeps 12 hours a day. and an adolexcent 8. . if an older person sleeps 6 is that ? natural" ? is natural a path to gene deterimined death. I think eating your ancestors diet is probably the worst thing. given that paradigm On Mon, Jun 22, 2015 at 1:00 AM, Peter Attia wrote: You and I are 100% aligned on that. Wait till I fill you in on my pharmaco strategy... Once we see your results, the fun starts. That said, the greatest first line medicine—as corny as this sounds—is what you eat. My goal is to combine the best evidence of diet/sleep/exercise/drugs/hormones into a super longevity package. Did I ever send you my manifesto? From: jeffrey E. [mailto:[email protected] <mailto:[email protected]> ] Sent: Sunday, June 21, 2015 9:42 PM To: Peter Attia Subject: Re: JASON conjecture - natural . is good when you are young. natural is bad when you are old. . proecting yourself FROM nature is the essence of longevity. your metformin is probably right on. .. you ve convinced me . I want to look to my ancestors only before the age of 40. after i want to look to modern science. On Sun, Jun 21, 2015 at 8:49 PM, Peter Attia wrote: 3 EFTA_R1_01334508 EFTA02353722

Agree that the data of the 50s mean little. I'm talking about a different problem, which is more social/behavioral than scientific. Understanding the nuances of WWI, II probably add little to understanding ISIL, but that's the "wrong" history. If ISIL is the focus, at least IMO, understanding FDR's relationship with Abdulaziz Ibn Saud does help, even though it took place 80 years ago. Our work in cancer and AD will be different, but in obesity there is likely no addressing the problem without some appreciation for how this mess was created. From: Jeffrey E. [mailto:[email protected] <mailto:[email protected]> Sent: Sunday, June 21, 2015 3:14 PM To: Peter Attia Subject: Re: JASON not at all, reading about world war one or two, or vietnam , gives me no insight into isil.. boko harem .etc. I listen to you becuse the science says x using tools of today any work using tools of yesterday, seems a little odd. germs before a microscope. etc. no data in the 50s worth noting. On Sun, Jun 21, 2015 at 5:47 PM, Peter Atti This isn't a diet book, in which case that info would be irrelevant. wrote: It's a book making the most provocative case ever in nutrition: our fundamental understanding obesity and disease might be wrong entirely. To make that case, GT needs to explain the history of how we got there. Can I understand WWII without understanding WWI? Maybe, but not nearly as well. Can a president make a rationale decision about invading Iraq without understanding the history of the tribes that make it up? Apparently not. Read this through the lens of "How can I take Peter seriously when he says X or Y about nutrition, when it so clearly flies in the face of my friends at NIH, CDC, FDA, ARA, ADA, ...?" From: Jeffrey E. [mailto:[email protected] <mailto:[email protected]> Sent: Sunday, June 21, 2015 2:03 PM To: Peter Attia 4 EFTA_R1_01334509 EFTA02353723