To: Jeffrey [email protected] From: [email protected] on behalf of Sent Wed 7/17/2013 3:51:36 AM Subject: Fwd: amyloid increases homocysteic acid toxicity Forwarded message From: Tohru Date: The, Jul 16, 2013 at 7:00 PM Suliect: am loid increases homoc stele acid toxici To Dear Christina; I am afraid Jeffrey has a question about the relationship between amyloid beta and homocysteic acid in blood for Alzheimer's disease process. Amyloid hypothesis is still valid for preventing AD. We already observed that homocysteic acid toxicity, especially, neurodegenerative toxicity, will increase in the presence of amyloid. However it has been observed that amyloid protein is present in normal brain, which shows that amyloid itself has no toxicity for brain work. Homocysteic acid has the original pathogen for AD process. Early onset of AD, familial AD, has higher production of amyloid, which increases the homocysteic acid toxicity, then very lower level of homocysteic acid can start the disease process. Recent reports indicate that ApoE4 increases the permeability of blood brain barrier, which allows the invasion of lower level of homocysteic acid in blood into brain. This my hypothesis is strongly supported by my TSH1 recovery, because TSH1 decreased homocysteic acid level in blood and blocked homocysteic acid toxicity in brain. Now I am sincerely request your support. EFTA_R1_00444219 EFTA01966177

Sincerely yours Tohru EFTA R1_00444220 EFTA01966178