Gain of function, loss of pain: November's monthly picks
To ensure you receive emails from Faculty of 1000, add [email protected] to your safelist. ----------------------------------------------------- Faculty of 1000 | http://f1000.com Monthly Update | November 2013 ----------------------------------------------------- ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ F1000Prime gets personal ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ We've introduced a new personalized homepage [ http://blog.f1000.com/2013/10/22/new-prime-homepage/ ] and email alert for all users of F1000Prime. Anyone can now create a highly personalized feed of articles recommended in F1000Prime, as well as new articles in PubMed, based on their own research interests. These new F1000Prime features are, for a limited time, freely available for a one-month personal trial to any individual who registers with F1000Prime [ http://f1000.com/prime/signin ]. All new and returning users of F1000Prime are invited to attend a free, live online demonstration [ http://blog.f1000.com/2013/10/25/attend-an-online-demonstration/ ] of the new features of F1000Prime. Find out more and register for a live demonstration here [ http://f1000prime.eventbrite.co.uk/ ]. --------------- Attend a live demo > > http://f1000prime.eventbrite.co.uk --------------- F1000Prime ================== 1,384 recommendations [ http://f1000.com/prime/search/evaluations ] added in the past month. Below is a selection: Gain, but no pain [ http://f1000.com/prime/718109968?key=nfcVk6cwEYxXGkh ] That a gain-of-function mutation in a channel expressed in nociceptor neurons leads to reduced pain sensation is, at first glance, very unexpected. Leipold E, Liebmann L, Korenke GC et al. Nat Genet. 2013 Nov; 45:1399-404 HIV vulnerability window [ http://f1000.com/prime/718106971?key=Q9i063B4JHKKYKB ] The first few hours to days of HIV or SIV infection is hypothesized as the window of vulnerability for the virus, which may have implications for prevention. Hansen SG, Piatak M, Ventura AB et al. Nature. 2013 Oct 3; 502:100-4 Potent anthrax antibiotic discovered [ http://f1000.com/prime/718056131?key=1NKc8UtLulRzFxU ] Though many new antibiotics are identified every year, truly structurally new antibiotics are rarely discovered, and this one is important for countering bioterrorism. Jang KH, Nam SJ, Locke JB et al. Angew Chem Int Ed Engl. 2013 Jul 22; 52:7822-4 * F1000Prime Reports * Open-access review journal [ http://f1000.com/prime/reports/ ], reporting on the hottest topics. The impact of thiopurines on surgical outcomes in inflammatory bowel disease: do they make a difference? [ http://f1000.com/prime/reports/m/5/50/ ] Increased and earlier use of azathioprine seems to reduce surgery rates in inflammatory bowel disease. F1000Prime Report by Vivek Chhaya and Richard Pollok [ http://f1000.com/prime/thefaculty/member/3467337218310302 ]. F1000Prime Rep 2013, 5:39 --------------- See all recent F1000Prime Reports >> http://f1000.com/prime/reports/ --------------- F1000Research ====================== Our innovative open access journal [ http://f1000research.com/ ] offering rapid publication, open peer review and open data. Below is a selection of our latest peer reviewed articles: COMMENTARY Advancing the activity cliff concept [ http://f1000research.com/articles/2-199/v1 ] [v1; ref status: indexed, http://f1000r.es/1wf [ http://f1000r.es/1wf ]] Published: 30 Sep 2013 Hu Y, Stumpfe D, Bajorath J. F1000Research 2:199 REVIEW Did the elimination of lead from petrol reduce crime in the USA in the 1990s? [ http://f1000research.com/articles/2-156/v2 ] [v2; ref status: indexed, http://f1000r.es/220 [ http://f1000r.es/220 ]] Latest Published: 08 Oct 2013 Hall W. F1000Research 2:156 SHORT RESEARCH ARTICLE Novel targets of miR-30, a microRNA required for biliary development [ http://f1000research.com/articles/2-197/v1 ] [v1; ref status: indexed, http://f1000r.es/1so [ http://f1000r.es/1so ]] Published: 24 Sep 2013 Le Guen CL, Friedman JR, Hand NJ. F1000Research 2:197 ---------------------------------------------- Submit now to F1000Research >> http://f1000research.com/author/submit ---------------------------------------------- ~~~~~~~~~~ Neuroscience meeting and data plotting tool > > http://f1000research-sfn13-mu.eventbrite.com/ ~~~~~~~~~~ We will be at the Society for Neuroscience meeting in San Diego, where we'll show you an exciting new feature of F1000Research that will allow you to interact in a new way with the data in our papers. You can find out more at our booth (222) at the exhibit or join us for a free drink at our reception on Mon 11 Nov. To attend the reception (also open to local researchers), register here [ http://f1000research-sfn13-mu.eventbrite.com/ ]. F1000Trials ================== A comprehensive listing [ http://f1000.com/trials ] of clinical trial articles reviewed by the F1000 Faculty, with the most important tagged as recommended. Below is a taster of F1000Trials content. To read, please sign-in [ http://f1000.com/trials/signin ] or register for free [ http://f1000.com/trials/register ]: Key to male vitality? [ http://f1000.com/trials/718106470?key=VO0mcidk4j8Xs2w ] Testosterone isn't the 'be all and end all' in men. Estrogen is shown to play a larger than expected role in body tone, strength and sexual function. Finkelstein JS, Lee H, Burnett-Bowie SA et al. N Engl J Med. 2013 Sep 12; 369:1011-22 Smoking gun for colon cancer [ http://f1000.com/trials/717996345?key=er5qbvZizM2MycY ] A phase III trial shows that smoking is significantly associated with less disease-free survival and time to recurrence of colon cancer. Phipps AI, Shi Q, Newcomb PA et al. J Clin Oncol. 2013 Jun 1; 31:2016-23 Hypnobirthing ineffective [ http://f1000.com/trials/718052146?key=y8AyONdv97jFXDH ] Proof from an RCT that antenatal hypnosis training does not lessen labor pain nor the amount of labor analgesia required during childbirth. Cyna A, Crowther C, Robinson J et al. BJOG. 2013 Sep; 120:1248-59 F1000Posters ====================== Open Repository [ http://f1000.com/posters ] for posters and slide presentations; completely free to view and submit. Below are a few selections: * NEUROSCIENCE * Looking at faces from different angles: Europeans fixate on different features in Asian and Caucasian faces [ http://f1000.com/posters/browse/summary/1094378 ] Brielmann A, BÜlthoff I, Armann R. F1000Posters 2013, 4:1163 * ECOLOGY * The Stonehenge landscape: restoring biodiversity and connectivity [ http://f1000.com/posters/browse/summary/1094414 ] Twiston-Davies G, Mitchley J, Mortimer S. F1000Posters 2013, 4:1145 * PSYCHIATRY * Metabolic parameters and risk for psychosis in adolescent [ http://f1000.com/posters/browse/summary/1094416 ] Demro C, Kline E, Bussell K et al. F1000Posters 2013, 4:1185 ---------------------------------------------- Deposit now >> http://f1000.com/posters/fordepositors ---------------------------------------------- ---------------------- * F1000Tips * Follow @F1000Tips on Twitter [ http://twitter.com/f1000tips ] for tips, tricks, and customer support for all Faculty of 1000 service: @F1000 | https://twitter.com/f1000 @F1000Trials | http://twitter.com/f1000trials @F1000Research | http://twitter.com/f1000research @F1000Posters | http://twitter.com/f1000posters ---------------------- ----------------------------------------------------- In addition to this Monthly Update, we also send out emails featuring deals and discounts for registered users. To sign up, registered users should visit MyF1000 via any F1000 product and opt-in to receive "Information from F1000 about special offers" (under Email Alerts). 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