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OF ELISA ZAFFARONI. This Trust Agreement ("the Trust") was executed by Dr. and Mrs. Alejandro C. Zaffaroni as Trustors. and by Matilda Nieri and Martin Gerstel as Trustees on December 3. 1989. _Martin Gerstel resigned as Trustee on March 1. 1995 and Jean Wirth accepted the appointment to be Successor Trust
upon your written acceptance of this appointment. Very truly yours, lead- ) Matilda Nieri mn cc: Dr. and Mrs. Alejandro Zaffaroni ACCEPTANCF OF SUCCFSSOR TRUSTEE I accept the nomination of Matilda Nieri and.agree to serve as successor Trustee of the Irrevocable Trust Agreement 4/15/89 for the benefit
OF ELISA ZAFFARONI. This Trust Agreement ("the Trust") was executed by Dr. and Mrs. Alejandro C. Zaffaroni as Trustors. and by Matilda Nieri and Martin Gerstel as Trustees on December 3. 1989. _Martin Gerstel resigned as Trustee on March 1. 1995 and Jean Wirth accepted the appointment to be Successor Trust
upon your written acceptance of this appointment. Very truly yours, lead- ) Matilda Nieri mn cc: Dr. and Mrs. Alejandro Zaffaroni ACCEPTANCF OF SUCCFSSOR TRUSTEE I accept the nomination of Matilda Nieri and.agree to serve as successor Trustee of the Irrevocable Trust Agreement 4/15/89 for the benefit
OF ELISA ZAFFARONI. This Trust Agreement ("the Trust") was executed by Dr. and Mrs. Alejandro C. Zaffaroni as Trustors. and by Matilda Nieri and Martin Gerstel as Trustees on December 3. 1989. _Martin Gerstel resigned as Trustee on March 1. 1995 and Jean Wirth accepted the appointment to be Successor Trust
upon your written acceptance of this appointment. Very truly yours, lead- ) Matilda Nieri mn cc: Dr. and Mrs. Alejandro Zaffaroni ACCEPTANCF OF SUCCFSSOR TRUSTEE I accept the nomination of Matilda Nieri and.agree to serve as successor Trustee of the Irrevocable Trust Agreement 4/15/89 for the benefit
Entities connected to both Martin Gerstel and SUCCFSSOR

Eric Holder
PERSONRedwood City
LOCATIONthe State of California
LOCATIONThis Trust Agreement
ORGANIZATIONAna Leech
PERSONBrandy Rock Way
LOCATIONMa Leech
PERSONELISA ZAFFARONI
PERSONJean Wirth's
PERSONLYDA ZAFFARONI
PERSONshari hPeAtc
PERSONRobert C. Mee
PERSONMatilda Nieri
ORGANIZATIONTrustee of the Elsa Zaffaroni Irrevocable Trust Agreement
ORGANIZATIONTrustors
ORGANIZATIONthe California Uniform Transfers to Minors
ORGANIZATIONTrusteeship
ORGANIZATIONAffymax N.V.
ORGANIZATIONGigapico, Inc.
ORGANIZATION