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to be Successor Trustee to Martin Gerstel on April 26. 1995. Jean Wirth died on November 8, 1996. Dear Ana: By this letter, I hereby appoint you, Ana Leech, to serve in Jean Wirth's place as successor Trustee of the Elsa Zaffaroni Irrevocable Trust Agreement dated 4/15/89 and executed on December 3, 19
and devise additional property to the Trustees to be held under and subject to all of the terms, ccr.ditions and provisions hereof, which property shari hPeAtc. part of the trust estate upon its acceptance by the Trustees. SECOND: During the lifetime of ELISA ZAFFARONI, the Trustees shall pay to or apply
to be Successor Trustee to Martin Gerstel on April 26. 1995. Jean Wirth died on November 8, 1996. Dear Ana: By this letter, I hereby appoint you, Ana Leech, to serve in Jean Wirth's place as successor Trustee of the Elsa Zaffaroni Irrevocable Trust Agreement dated 4/15/89 and executed on December 3, 19
and devise additional property to the Trustees to be held under and subject to all of the terms, ccr.ditions and provisions hereof, which property shari hPeAtc. part of the trust estate upon its acceptance by the Trustees. SECOND: During the lifetime of ELISA ZAFFARONI, the Trustees shall pay to or apply
to be Successor Trustee to Martin Gerstel on April 26. 1995. Jean Wirth died on November 8, 1996. Dear Ana: By this letter, I hereby appoint you, Ana Leech, to serve in Jean Wirth's place as successor Trustee of the Elsa Zaffaroni Irrevocable Trust Agreement dated 4/15/89 and executed on December 3, 19
and devise additional property to the Trustees to be held under and subject to all of the terms, ccr.ditions and provisions hereof, which property shari hPeAtc. part of the trust estate upon its acceptance by the Trustees. SECOND: During the lifetime of ELISA ZAFFARONI, the Trustees shall pay to or apply
Entities connected to both Ana Leech and shari hPeAtc

Eric Holder
PERSONRedwood City
LOCATIONthe State of California
LOCATIONThis Trust Agreement
ORGANIZATIONBrandy Rock Way
LOCATIONMa Leech
PERSONELISA ZAFFARONI
PERSONMartin Gerstel
PERSONJean Wirth's
PERSONLYDA ZAFFARONI
PERSONRobert C. Mee
PERSONMatilda Nieri
ORGANIZATIONTrustee of the Elsa Zaffaroni Irrevocable Trust Agreement
ORGANIZATIONSUCCFSSOR
ORGANIZATIONTrustors
ORGANIZATIONthe California Uniform Transfers to Minors
ORGANIZATIONTrusteeship
ORGANIZATIONAffymax N.V.
ORGANIZATIONGigapico, Inc.
ORGANIZATION