Epstein Secrets

ve each of the family member's genomes sequenced. The genome tests gave Ivana and Antonia the bad news about calpainopathy. Their younger brother, Mario, is free of the disease. Scientists classify calpainopathy, or "calpain," as a limb-girdle muscular dystrophy Type 2a, caused by a mutation in the

tly available drugs might target the troublemaker mutations. Combining whole genome sequencing, exome sequencing, and RNA expression analysis—what Washington University pro- fessor of genetics and Genome Institute co-director Elaine Mardis calls the "Maserati approach"—the team compares a comprehensive genetic prof

ntation of tool use in humans and monkeys: common and uniquely human features. Journal of Neuroscience, 29(37), 11523-11539; Preuss, Todd M, Caceres, Mario, Oldham, Michael C, & Geschwind, Daniel H. (2004). Human brain evolution: insights from microarrays. Nature reviews Genetics, 5(11), 850-860; Rilling

appeared in print, also in a distinguished scientific journal. But this time there was no media fanfare. The new work was carried out by Min Zhuo at Washington University, an ex-member of Tsien’s lab and a co- author of the original paper. Zhuo’s new paper confirmed that memory-enhanced mice were indeed smarter, but al

xome sequencing, and RNA expression analysis—what Washington University pro- fessor of genetics and Genome Institute co-d

have each of the family member’s genomes sequenced. The genome tests gave Ivana and Antonia the bad news about calpainopathy. Their younger brother, Mario, is free of the disease. Scientists classify calpainopathy, or “calpain,” as a limb-girdle muscular dystrophy Type 2a, caused by a mutation in the g